I wonder if the higher proportion of stromal cells in young tumors is a direct result of specific dietary components or gut microbiome variations rather than just inherent biology. The study mentions looking at how cell programs interact with diet and microbes, but it seems early onset cases often present with distinct inflammatory profiles in the colon itself before tumor formation.
It would be interesting to see if these long non-coding RNAs show up consistently in pre cancerous polyps in younger patients or only after malignant transformation. If they are elevated early on, that could actually help solve the diagnosis problem where many late stage cancers are found, assuming we can target them specifically.
Does this track differences between generations (i.e. environmental changes), or the age-related differences within a single cohort, or somehow both at once?
not sure if that makes it better for you, but usually you are knocked out and don't know what is happening during the procedure. Much worse is the preparation starting days before with disgustingly tasting things that intentionally give you diarrhea (and maybe make you puke) to clear the path, and no food at all
People get a safe but vile-tasting laxative by default. If you don't have any known problems with your colon then you could ask for a faster-acting laxative that is easier to get down.
I have a condition, so I have a colonoscopy every year. Once I had found out about there being a fast-acting alternative, I've always chosen that.
I've never done it sedated. I prefer to watch the screen and and ask questions. I've found it quite fascinating, actually.
The doctors and nurses have always been professional, focused on the colon: not the butt. There is absolutely nothing sexual about it. I've never felt pain: only some tension, and that's been because of gas (needed to get a clear view). It is perfectly safe unless your colon has some illness of some sort.
The worst part has always been the prep.
I don't intend to disagree, merely to suggest that while doing the right thing one would be best off considering the potential aspects inflicted to themselves, in this case colonoscopy deaths are one in ten thousand from memory
cobaltpath | 4 hours ago
It would be interesting to see if these long non-coding RNAs show up consistently in pre cancerous polyps in younger patients or only after malignant transformation. If they are elevated early on, that could actually help solve the diagnosis problem where many late stage cancers are found, assuming we can target them specifically.
yread | an hour ago
andai | 2 hours ago
Spacecosmonaut | an hour ago
Adenoma found and removed.
This is a type of cancer that is almost entirely preventable with screening. Get your tubes checked.
sevenzero | an hour ago
Spacecosmonaut | an hour ago
sevenzero | 53 minutes ago
ackbar03 | 47 minutes ago
taskforcegemini | 31 minutes ago
Findecanor | 17 minutes ago
I have a condition, so I have a colonoscopy every year. Once I had found out about there being a fast-acting alternative, I've always chosen that.
I've never done it sedated. I prefer to watch the screen and and ask questions. I've found it quite fascinating, actually. The doctors and nurses have always been professional, focused on the colon: not the butt. There is absolutely nothing sexual about it. I've never felt pain: only some tension, and that's been because of gas (needed to get a clear view). It is perfectly safe unless your colon has some illness of some sort. The worst part has always been the prep.
thin_carapace | an hour ago
Spacecosmonaut | 58 minutes ago
hawk_ | an hour ago
Spacecosmonaut | an hour ago
hawk_ | 27 minutes ago
solids | 9 minutes ago